Napoli easily beat Frosinone by 5-1 and move on top of the Serie A table just as Inter Milan suffered a shock deafeat to Sassuolo on home ground.
Gonzalo Higuain scored twice to make it 20 goals in all competitions this season, and Napoli moved two points clear of Inter Milan.
There were already speculations earlier that Napoli could potentially win the Italian top flight and take their first league trophy since football legend Diego Maradona lead them to it more than 20 years ago.
Inter Milan was leading the table before their surprising loss to Sassuolo.
The game was heading for a goalless draw when Inter defender Joao Miranda fouled Gregoire Defrel inside the area.
Domenico Berardi netted the penalty to condemn Roberto Mancini’s side to a third defeat in six Serie A games.
Meanwhile, Juventus marked their ninth straight win by a narrow victory of 2-1 against Sampdoria and moved above Inter too, level at 39 points but with goal difference advantage.